[HTML][HTML] Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank
Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural
somatic event. Previous studies have indicated age and cigarette smoking increase the risk
of mLOY, but the relationship of other exposures with mLOY and mLOY with disease has not
been adequately investigated. We characterized mLOY in a large cohort of 223,338 men
from the UK Biobank by scanning for deviations in genotyping array median log2 intensity
ratios (mLRR) of the Y chromosome using a standard algorithm. A total of 3,789 (1.7%) men …
somatic event. Previous studies have indicated age and cigarette smoking increase the risk
of mLOY, but the relationship of other exposures with mLOY and mLOY with disease has not
been adequately investigated. We characterized mLOY in a large cohort of 223,338 men
from the UK Biobank by scanning for deviations in genotyping array median log2 intensity
ratios (mLRR) of the Y chromosome using a standard algorithm. A total of 3,789 (1.7%) men …
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